My monitor is 25" ,plenty space. It's cluttered because I'm interested in many diff areas of interest: art, music, computers, history, knitting, archaelogy, politics, science. The profile I use for MT is much simpler.
I have an extension called custom buttons, where I have icons for the pages I most commonly visit. I have bookmark toolbars on top and left. I have an adblocker, several extra security features, overlay remover, cookie monitor, password manager, text formatting toolbar, about 20 extensions total. Because it is so customiuzable, you can make it as simple or complex as you want. The best thing is I don't have that huge piece of Google spyware called Chrome.